BDBM304667 (S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((S)-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl)methyl)piperazine::US10144715, Compound 48-63

SMILES CS(=O)(=O)c1cccc(c1)N1CCN(C[C@H]2CCN(CC(F)(F)F)C2)[C@H](C1)c1ccccc1

InChI Key InChIKey=ASEZPZHKRBKKJY-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304667   

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304667BDBM304667((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((S)-...)
Affinity DataEC50:  1.55E+3nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304667BDBM304667((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((S)-...)
Affinity DataKi: >2.50E+3nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304667BDBM304667((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((S)-...)
Affinity DataKi: >3.33E+3nMAssay Description:Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 304667BDBM304667((S)-4-(3-(methylsulfonyl)phenyl)-2-phenyl-1-(((S)-...)
Affinity DataEC50:  1.17E+4nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent