BDBM306641 (1S,8R)-N-[(4- carbamimidoylphenyl) methyl]-12-(2- fluoropropan-2-yl)-15- oxatetracyclo- [6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 284

SMILES CC(C)(F)c1ccc2[C@@H]3O[C@@H](c4cc(ccc34)C(=O)NCc3ccc(cc3)C(N)=N)c2c1

InChI Key InChIKey=RYCBNERCLXZHOG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306641   

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306641(US10144746, Compound 284 | (1S,8R)-N-[(4- carbamim...)
Affinity DataIC50: 6.31nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent