BDBM306691 (1S,8R)-N-[(4-carbamimidoyl- 2,6-difluoro-phenyl)methyl]- 12-(1,1-dioxo-1lambda6-thiomorpholin- 4-yl)-15-oxatetracyclo- [6.6.1.02,7.09,14]pentadeca- 2,4,6,9,11,13-hexaene-4- carboxamide::US10144746, Compound 336

SMILES NC(=N)c1cc(F)c(CNC(=O)c2ccc3[C@H]4O[C@H](c5cc(ccc45)N4CCS(=O)(=O)CC4)c3c2)c(F)c1

InChI Key InChIKey=XTPINWBFBVZCKT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 306691   

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM306691(US10144746, Compound 336 | (1S,8R)-N-[(4-carbamimi...)
Affinity DataIC50: 5.01nMAssay Description:The chromogenic substrate D-Pro-Phe-Arg-pNa, 2HCl (BIOPHEN CS-31(02) from Hyphen BioMed, Neuville-Sur-oise, France) was dissolved in 5 mL deionized w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent