BDBM307574 ((2R,4R)-4-((4-(2,2- difluoroethoxy)pyridin-2-yl)amino)-2- methylpyrrolidin-1-yl)(2,3-dihydro-1H- inden-4-yl)methanone::US10150751, Example 7

SMILES C[C@@H]1C[C@H](CN1C(=O)c1cccc2CCCc12)Nc1cc(OCC(F)F)ccn1

InChI Key InChIKey=MGWMVTIDKSMIFP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307574   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307574(US10150751, Example 7 | ((2R,4R)-4-((4-(2,2- diflu...)
Affinity DataIC50: 2.00E+3nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307574(US10150751, Example 7 | ((2R,4R)-4-((4-(2,2- diflu...)
Affinity DataIC50: 1.00E+4nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent