BDBM307582 2-(((3R,5R)-1-(2-(2H-1,2,3-triazol-2- yl)benzoyl)-5-methylpyrrolidin-3-yl)amino)- 4-methoxynicotinonitrile::US10150751, Example 18

SMILES COc1ccnc(N[C@@H]2C[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)c1C#C

InChI Key InChIKey=QUWKFNBAVKKCTP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307582   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307582(US10150751, Example 18 | 2-(((3R,5R)-1-(2-(2H-1,2,...)
Affinity DataIC50: 167nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307582(US10150751, Example 18 | 2-(((3R,5R)-1-(2-(2H-1,2,...)
Affinity DataIC50: 1.00E+4nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent