BDBM307604 (3-(1H-Pyrazol-1-yl)pyrazin-2- yl)((2R,4R)-4-((3-methoxypyridin-2- yl)amino)-2-methylpyrrolidin-1- yl)methanone::US10150751, Example 43

SMILES COc1cccnc1N[C@@H]1C[C@@H](C)N(C1)C(=O)c1nccnc1-n1cccn1

InChI Key InChIKey=VYBLMOVJAQIVKL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307604   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307604(US10150751, Example 43 | (3-(1H-Pyrazol-1-yl)pyraz...)
Affinity DataIC50: 1.50E+3nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307604(US10150751, Example 43 | (3-(1H-Pyrazol-1-yl)pyraz...)
Affinity DataIC50: 1.00E+4nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent