BDBM307608 ((2S,4S)-4-((4-methoxypyridin-2- yl)amino)-2-methylpyrrolidin-1-yl)(2- (trifluoromethoxy)phenyl)methanone::US10150751, Example 47

SMILES COc1cccnc1N[C@@H]1C[C@@H](C)N(C1)C(=O)c1ccccc1OC(F)(F)F

InChI Key InChIKey=PUPBNSXIIGNQNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307608   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307608(US10150751, Example 47 | ((2S,4S)-4-((4-methoxypyr...)
Affinity DataIC50: 41nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307608(US10150751, Example 47 | ((2S,4S)-4-((4-methoxypyr...)
Affinity DataIC50: 3.95E+3nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent