BDBM307638 2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridin-2-yl)-5- (1-methyl-1H- imidazol-4- yl)isoindolin-1-one::US10150755, Compound 30

SMILES Cn1cnc(c1)-c1ccc2C(=O)N(Cc2c1)c1cccc(n1)-c1nncn1C1CC1

InChI Key InChIKey=ATVWMGIUIKAOFB-UHFFFAOYSA-N

Data  2 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307638   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Seal Rock Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 307638BDBM307638(US10150755, Compound 30 | 2-(6-(4-cyclopropyl- 4H-...)
Affinity DataIC50: 200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent

TargetMyosin light chain kinase, smooth muscle(Human)
Seal Rock Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 307638BDBM307638(US10150755, Compound 30 | 2-(6-(4-cyclopropyl- 4H-...)
Affinity DataKd:  6.00E+3nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent