BDBM307664 2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-6-(2-cyclopropylpyrimidin-5-yl)isoindolin-1-one ::US10150755, Compound 56

SMILES O=C1N(Cc2ccc(cc12)-c1cnc(nc1)C1CC1)c1cccc(n1)-c1nncn1C1CC1

InChI Key InChIKey=DODPWPIQCPQNBS-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307664   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307664(US10150755, Compound 56 | 2-(6-(4-cyclopropyl-4H-1...)
Affinity DataIC50: 200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Seal Rock Therapeutics

US Patent
LigandPNGBDBM307664(US10150755, Compound 56 | 2-(6-(4-cyclopropyl-4H-1...)
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent