BDBM307813 BDBM307917::N-{5-chloro-4-[1-(3-fluorobenzyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-6-azaspiro[3.4]octan-2-amine::US9650358, Example 109

SMILES Fc1cccc(Cn2cnc3ccc(cc23)-c2cc(NC3CC4(C3)CCNC4)ncc2Cl)c1

InChI Key InChIKey=QOTRYAPOAVNNAL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307813   

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM307813(US9650358, Example 109 | N-{5-chloro-4-[1-(3-fluor...)
Affinity DataIC50: 19nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM307813(US9650358, Example 109 | N-{5-chloro-4-[1-(3-fluor...)
Affinity DataIC50: 54nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent