BDBM308166 US9650377, Example 90

SMILES CCCc1cccc2C3=CC(=NCC(=O)N3CCc12)n1cnc(C)c1

InChI Key InChIKey=DNSXDCQMCGOQBC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 308166   

TargetMetabotropic glutamate receptor 5(Human)
Novartis

US Patent
LigandPNGBDBM308166(US9650377, Example 90)
Affinity DataIC50: 10nMAssay Description:Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 1(Human)
Novartis

US Patent
LigandPNGBDBM308166(US9650377, Example 90)
Affinity DataIC50: 1.50E+3nMAssay Description:Activity of compounds of the present invention was examined by determination to what extent the glutamate-induced elevation of the intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent