BDBM310682 (S)-5-(2-Chloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2-hydroxy-2-methylpropyl)-4-(2-methylpyrrolidine-1-carbonyl)thiazole-2-carboxamide::US10150762, Example 15/10

SMILES C[C@H]1CCCN1C(=O)c1nc(sc1-c1ccc(cc1Cl)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCC(C)(C)O

InChI Key InChIKey=PHSWOIBLKMOXAV-NSHDSACASA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310682   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310682((S)-5-(2-Chloro-4-(1,1,1,3,3,3-hexafluoro-2-hydrox...)
Affinity DataIC50:  7.90nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310682((S)-5-(2-Chloro-4-(1,1,1,3,3,3-hexafluoro-2-hydrox...)
Affinity DataKd:  0.260nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent