BDBM310696 4-(7-Azabicyclo[2.2.1]heptane-7-carbonyl)-5-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-methylphenyl)-N-(2-hydroxy-2-methylpropyl)thiazole-2-carboxamide::US10150762, Example 21/3

SMILES Cc1cc(ccc1-c1sc(nc1C(=O)N1C2CCC1CC2)C(=O)NCC(C)(C)O)C(O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=LVWHDXHEMBLOGO-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 310696   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310696(4-(7-Azabicyclo[2.2.1]heptane-7-carbonyl)-5-(4-(1,...)
Affinity DataIC50:  15nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM310696(4-(7-Azabicyclo[2.2.1]heptane-7-carbonyl)-5-(4-(1,...)
Affinity DataKd:  2.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent