BDBM311001 US10155727, Example 56::USRE49517, Example 56

SMILES Cc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1

InChI Key InChIKey=JUIQWZMUESSJRP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 311001   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM311001(US10155727, Example 56 | USRE49517, Example 56)
Affinity DataIC50: 78.7nMAssay Description:After thawing on the day of the assay, the membrane suspension was diluted further with 20 mM HEPES/0.1 mM KCl/pH 7.2.The incubation mixture of 200 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetGlutamate receptor ionotropic, NMDA 2B(Rat)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM311001(US10155727, Example 56 | USRE49517, Example 56)
Affinity DataIC50: 78.7nMAssay Description:After thawing on the day of the assay, a 5 ml membrane aliquot was centrifuged at 48000 g for 30 min at 4° C. The pellet was resuspended in 5 ml of 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM311001(US10155727, Example 56 | USRE49517, Example 56)
Affinity DataIC50: 9.38E+4nMAssay Description:Binding was terminated by filtration of the incubated membrane preparations using Filtermat B (Pharmacia, Uppsala Sweden) and a Micro Cell Harvester ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent