BDBM311978 US10166214, Example 114::US10166214, Example 115::US10166214, Example 116::US10675268, Example 116

SMILES CC(NC(=O)[C@@H]1[C@H]2CNC[C@@H]12)c1nn(C)c2c(Cl)cccc12

InChI Key InChIKey=MDEPRAWYCUAGJJ-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 311978   

TargetSomatostatin receptor type 4(Human)
Centrexion Therapeutics

US Patent
LigandPNGBDBM311978(US10166214, Example 114 | US10166214, Example 115 ...)
Affinity DataEC50:  2.10nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Centrexion Therapeutics

US Patent
LigandPNGBDBM311978(US10166214, Example 114 | US10166214, Example 115 ...)
Affinity DataEC50:  2.10nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Centrexion Therapeutics

US Patent
LigandPNGBDBM311978(US10166214, Example 114 | US10166214, Example 115 ...)
Affinity DataEC50:  4.70nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Centrexion Therapeutics

US Patent
LigandPNGBDBM311978(US10166214, Example 114 | US10166214, Example 115 ...)
Affinity DataEC50:  4.70nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Centrexion Therapeutics

US Patent
LigandPNGBDBM311978(US10166214, Example 114 | US10166214, Example 115 ...)
Affinity DataEC50:  21.3nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Centrexion Therapeutics

US Patent
LigandPNGBDBM311978(US10166214, Example 114 | US10166214, Example 115 ...)
Affinity DataEC50:  21.3nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent