BDBM312137 6-hydroxy-2-(4-hydroxyphenyl)-4-phenylisoquinolin-1(2H)-one::US9604931, 15a::US9623021, Compound 15b

SMILES Oc1ccc(cc1)-n1cc(-c2ccccc2)c2cc(O)ccc2c1=O

InChI Key InChIKey=YECTYKMUECXIIC-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 312137   

TargetSteroid hormone receptor ERR2(Human)
Gtx

US Patent
LigandPNGBDBM312137(US9604931, 15a | 6-hydroxy-2-(4-hydroxyphenyl)-4-p...)
Affinity DataKi:  130nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetEstrogen receptor beta(Human)
Gtx

US Patent
LigandPNGBDBM312137(US9604931, 15a | 6-hydroxy-2-(4-hydroxyphenyl)-4-p...)
Affinity DataKi:  252nMAssay Description:Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetSteroid hormone receptor ERR1(Human)
Gtx

US Patent
LigandPNGBDBM312137(US9604931, 15a | 6-hydroxy-2-(4-hydroxyphenyl)-4-p...)
Affinity DataKi:  1.78E+3nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetEstrogen receptor(Human)
Gtx

US Patent
LigandPNGBDBM312137(US9604931, 15a | 6-hydroxy-2-(4-hydroxyphenyl)-4-p...)
Affinity DataKi:  2.10E+3nMAssay Description:Recombinant ER-α or ER-β ligand binding domain (LBD) was combined with [3H]E2 (PerkinElmer, Waltham, Mass.) in buffer A (10 mM Tris, pH 7.4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent