BDBM312566 2-[4-(1-Aminocyclobutyl)phenyl]-7,8-dimethyl-3-phenylimidazo[1,2-b]-pyridazine-6-carboxamide::US9604989, Example 52

SMILES Cc1c(C)c2nc(c(-c3ccccc3)n2nc1C(N)=O)-c1ccc(cc1)C1(N)CCC1

InChI Key InChIKey=LUNBVUYIAYCSPQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312566   

TargetRAC-beta serine/threonine-protein kinase(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM312566(US9604989, Example 52 | 2-[4-(1-Aminocyclobutyl)ph...)
Affinity DataIC50: 15nMAssay Description:His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM312566(US9604989, Example 52 | 2-[4-(1-Aminocyclobutyl)ph...)
Affinity DataIC50: 26nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent