BDBM312669 N-[1-[1-(3- acetamidopropyl)-4- piperidyl]-3-[5-chloro-2- (difluoromethoxy)phenyl] pyrazol-4-yl]-2-amino- pyrazolo[1,5- a]pyrimidine-3- carboxamide::US9604984, Example 150

SMILES CC(=O)NCCCN1CCC(CC1)N\C=C(\NC(=O)C(\C(N)=N)=C1\NC=CC=N1)C(=N)c1cc(Cl)ccc1OC(F)F

InChI Key InChIKey=OWEZXPGJBKGANV-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 312669   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM312669(US9604984, Example 150 | N-[1-[1-(3- acetamidoprop...)
Affinity DataKi:  0.170nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM312669(US9604984, Example 150 | N-[1-[1-(3- acetamidoprop...)
Affinity DataKi:  0.730nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
US Patent