BDBM312697 US9604998, Example 96

SMILES COc1c(CCN2CCN3C[C@@H](OC[C@@H]3C2)c2ccc3C(=O)OCc3c2C)ccc(C#N)c1F

InChI Key InChIKey=ZBJOUPQTHHGLIE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312697   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM312697(US9604998, Example 96)
Affinity DataIC50: 80nMAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent