BDBM313052 N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-1-cyanocyclobutanecarboxamide::US9605007, Example 108::US9744173, Example 108

SMILES C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)C2(CCC2)C#N)cs1

InChI Key InChIKey=XZKSIVHILMPFLG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 313052   

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM313052(US9605007, Example 108 | N-{2-[(4aR,6S,8aR)-2-amin...)
Affinity DataIC50: 94nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Pfizer

US Patent
LigandPNGBDBM313052(US9605007, Example 108 | N-{2-[(4aR,6S,8aR)-2-amin...)
Affinity DataIC50: 94nMAssay Description:Beta-secretase (BACE) is one of the enzymes involved in the generation of the amyloid beta peptide found in the amyloid plaques of Alzheimer's Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent