BDBM31313 1,4-benzodiazepine-2,5-dione, 12j

SMILES CC#Cc1ccc2N(CCN3CCOCC3)C(=O)[C@@H](N([C@H](C)c3ccc(Cl)cc3N)C(=O)c2c1)c1ccc(Cl)cc1

InChI Key InChIKey=LQZUTIMEANELKZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31313   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31313(1,4-benzodiazepine-2,5-dione, 12j)
Affinity DataIC50: 787nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed