BDBM313310 US10166249, Example 544::US10166249, Example 545

SMILES COc1cccc(OCCC2CCc3cc(ccc3C2)[C@H]2CC[C@](N)(COP(O)(O)=O)C2)c1

InChI Key InChIKey=NGSXKSFLSBZWFC-UHFFFAOYSA-N

Data  2 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 313310   

TargetSphingosine-1-phosphate lyase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataEC50: <10nMAssay Description:hS1P1/CHO cells were plated into BD Amine 384-well plates the day before the assay. On the day of the assay, growth medium was removed and replaced w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetSphingosine-1-phosphate lyase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataEC50: <10nMAssay Description:hS1P1/CHO cells were plated into BD Amine 384-well plates the day before the assay. On the day of the assay, growth medium was removed and replaced w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetSphingosine-1-phosphate lyase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataEC50:  55nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetSphingosine-1-phosphate lyase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataIC50: 55nMAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1×109 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetSphingosine-1-phosphate lyase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataIC50: 55nMAssay Description:Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1×109 cells/pellet) were suspended in buffer containing 20 mM HEPES (4-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataEC50: >625nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataEC50: >625nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent

TargetSphingosine-1-phosphate lyase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM313310(US10166249, Example 545 | US10166249, Example 544)
Affinity DataEC50:  5.50E+3nMAssay Description:Compounds were loaded in a 384 Falcon v-bottom plate (0.5 l/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-Gal5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
US Patent