BDBM31379 CHEMBL28872::terephthalamide scaffold, 27

SMILES COC(=O)[C@@H](CC(C)C)NC(=O)c1ccc(cc1OC)C(=O)N(C(C)C)C(C)C

InChI Key InChIKey=JWRGNFHTVQYFTF-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 31379   

TargetBcl-2-like protein 1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM31379(CHEMBL28872 | terephthalamide scaffold, 27)
Affinity DataKi:  1.79E+3nMAssay Description:Binding affinity for Bcl-xL was assessed by a fluorescence polarization assay using a fluorescently labeled 16-mer Bak-peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM31379(CHEMBL28872 | terephthalamide scaffold, 27)
Affinity DataKi:  1.79E+3nM ΔG°:  -7.83kcal/molepH: 7.4 T: 2°CAssay Description:Fluorescence polarization experiments were conducted on a Photon Technology International instrument using a 0.3 cm path length cuvette. Spectra were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed