BDBM314091 2,6-dimethyl-N-(4-(2-oxopiperidin-4-yl)benzyl)benzamide::US9610299, Example 6

SMILES Cc1cccc(C)c1C(=O)NCc1ccc(cc1)C1CCNC(=O)C1

InChI Key InChIKey=ARCMHOCAICWNFM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 314091   

TargetAldehyde dehydrogenase, mitochondrial(Human)
Gilead Sciences

US Patent
LigandPNGBDBM314091(2,6-dimethyl-N-(4-(2-oxopiperidin-4-yl)benzyl)benz...)
Affinity DataIC50: 1.11E+3nMAssay Description:Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Gilead Sciences

US Patent
LigandPNGBDBM314091(2,6-dimethyl-N-(4-(2-oxopiperidin-4-yl)benzyl)benz...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Gilead Sciences

US Patent
LigandPNGBDBM314091(2,6-dimethyl-N-(4-(2-oxopiperidin-4-yl)benzyl)benz...)
Affinity DataIC50: 1.30E+5nMAssay Description:MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent