BDBM314751 3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-ethyl-3,4,7,9-tetrahydro-1H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidine-2,8-dione::US9611267, Example 63

SMILES CCN1C(=O)N(Cc2ccc3NC(=O)Cc3c12)c1c(Cl)c(OC)cc(OC)c1Cl

InChI Key InChIKey=UBGOCIHVUFNXKT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 314751   

TargetFibroblast growth factor receptor 2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM314751(3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-ethyl-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM314751(3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-ethyl-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte Holdings

US Patent
LigandPNGBDBM314751(3-(2-chloro-6-fluoro-3,5-dimethoxyphenyl)-1-ethyl-...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
US Patent