BDBM315207 ((3R/S)-3-[3-({(2R/S)-2-[4-(5-Chloropyridin-3-yl)-3-fluorophenyl]-2-cyclobutylacetyl}amino)-2-methylphenyl]butanoic acid::US10172814, Example 149::US10172814, Example 150::US10172814, Example 151::US10172814, Example 152::US10172814, Example 153

SMILES CC(CC(O)=O)c1cccc(NC(=O)C(C2CCC2)c2ccc(c(F)c2)-c2cncc(Cl)c2)c1C

InChI Key InChIKey=CYPUGHFYVJHLOZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315207   

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315207(US10172814, Example 150 | US10172814, Example 151 ...)
Affinity DataIC50: 11.7nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315207(US10172814, Example 150 | US10172814, Example 151 ...)
Affinity DataIC50: 46.5nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315207(US10172814, Example 150 | US10172814, Example 151 ...)
Affinity DataIC50: 52.1nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315207(US10172814, Example 150 | US10172814, Example 151 ...)
Affinity DataIC50: 914nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetProstaglandin G/H synthase 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM315207(US10172814, Example 150 | US10172814, Example 151 ...)
Affinity DataIC50: 2.62E+3nMAssay Description:Recombinant proteins (human isoforms) of PTGES containing a FLAG tag, expressed in baculovirus infected insect cells (Hi-5) and purified by affinity ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent