BDBM315499 US10172858, Table 1.22

SMILES CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc12

InChI Key InChIKey=GYLDXIAOMVERTK-UHFFFAOYSA-N

Data  4 KI  7 IC50  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 315499   

TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataKi:  1.40nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of mTOR in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proli...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of mTOR in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous on...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50:  5.30nMAssay Description:Inhibition of PI3K beta (unknown origin) by PIP3 production detection based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of mTOR in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataIC50: 10nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataIC50: 13nMAssay Description:Inhibition of mTOR in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one so...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataIC50: 13nMAssay Description:Inhibition of mTOR in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Shandong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataIC50: 36nMAssay Description:Inhibition of mTOR in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifer...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50: >100nMAssay Description:Inhibition of PIK3C2A (unknown origin) by PIP3 production detection based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataKi:  152nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataKi:  165nMAssay Description:Inhibition of PI3Kgamma (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50:  219nMAssay Description:Inhibition of PI3K alpha (unknown origin) by PIP3 production detection based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50:  221nMAssay Description:Inhibition of PI3K gamma (unknown origin) by PIP3 production detection based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of PIK3C2B (unknown origin) by PIP3 production detection based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Georgetown University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of human VPS34 assessed as reduction in PIP3 product complex formationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50:  5.29E+3nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formationMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Georgetown University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50:  5.62E+3nMAssay Description:Inhibition of human VPS34 assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P ELIS...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 315499BDBM315499(US10172858, Table 1.22)
Affinity DataEC50:  6.84E+3nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P E...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed