BDBM315813 4-(4-Chloro-2-fluoro- 5-imidazo[1,2-b]- pyridazin-6-ylmethyl- phenyl)-7-morpholin- 4-ylquinazoline1H NMR (500 MHz, DMSO-d6) ppm = 9.10 (s,1H), 8.22 (s, 1H), 8.07 (d, J = 9.4, 1H), 7.78-7.74(m, 2H), 7.74-7.71 (m, 1H), 7.60 (dd, J = 9.4, 3.1,1H), 7.54 (dd, J = 9.4, 2.5, 1H), 7.20 (d, J = 2.5, 1H),7.16 (d, J = 9.4, 1H), 4.42 (s, 2H), 3.80-3.75 (m,4H), 3.47-3.43 (m, 4H).::US10172859, Example 235::US11065253, Example 235::US9732094, Example 235

SMILES Fc1cc(Cl)c(Cc2ccc3nccn3n2)cc1-c1ncnc2cc(ccc12)N1CCOCC1

InChI Key InChIKey=INTDVNQLZOTAHT-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315813   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315813(US10172859, Example 235 | 4-(4-Chloro-2-fluoro- 5-...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315813(US10172859, Example 235 | 4-(4-Chloro-2-fluoro- 5-...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315813(US10172859, Example 235 | 4-(4-Chloro-2-fluoro- 5-...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315813(US10172859, Example 235 | 4-(4-Chloro-2-fluoro- 5-...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315813(US10172859, Example 235 | 4-(4-Chloro-2-fluoro- 5-...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent