BDBM315828 US10172859, Example 249::US10172859, Example 250::US10172859, Example 266::US11065253, Example 266::US9732094, Example 266::[2-Chloro-4-fluoro-5- (5-fluoro-7- morpholin-4-yl- quinazolin-4-yl)- phenyl]-(3-methoxy- pyrazin-2-yl)- methanol (Ena 2)see racemate

SMILES COc1nccnc1C(O)c1cc(c(F)cc1Cl)-c1ncnc2cc(cc(F)c12)N1CCOCC1

InChI Key InChIKey=OWOGJPGABWHWIU-UHFFFAOYSA-N

Data  6 KI  9 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 315828   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy BDB DOIUS Patent

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TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/19/2021
Entry Details
Copy BDB DOIUS Patent

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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/30/2019
Entry Details
Copy BDB DOIUS Patent

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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent

LigandBDBM315828(US10172859, Example 266 | [2-Chloro-4-fluoro-5- (5...)Copy SMILESCopy InChI

Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2019
Entry Details
Copy BDB DOIUS Patent

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