BDBM315919 US10172859, Example 343::US10172859, Example 344::US10172859, Example 399::US11065253, Example 399::US9732094, Example 399::[4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]-[1,2,4]- triazolo[4,3-a]pyridin- 3-ylmethanol (Ena 2)see racemate

SMILES OC(c1nnc2ccccn12)c1ccc(F)c(c1)-c1ncnc2cc(ccc12)N1CCOCC1

InChI Key InChIKey=WKLHRHOHIWMJCS-UHFFFAOYSA-N

Data  6 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 315919   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi:  2.00E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi:  2.00E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315919([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent