BDBM315930 (3,5-Dimethyl- pyrazin-2-yl)-[4- fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.09 (s,1H), 8.30 (s, 1H), 7.60-7.50 (m, 4H), 7.41-7.33(m, 1H), 7.23-7.17 (m, 1H), 6.20 (d, J = 5.4, 1H),6.04 (d, J = 5.2, 1H), 3.81-3.76 (m, 4H), 3.47-3.42 (m, 4H), 2.50 (s, 3H), 2.43 (s, 3H).::US10172859, Example 354::US11065253, Example 354::US9732094, Example 354

SMILES Cc1cnc(C(O)c2ccc(F)c(c2)-c2ncnc3cc(ccc23)N2CCOCC2)c(C)n1

InChI Key InChIKey=PCLBXBKEXTTXEW-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 315930   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315930(US10172859, Example 354 | (3,5-Dimethyl- pyrazin-2...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315930(US10172859, Example 354 | (3,5-Dimethyl- pyrazin-2...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM315930(US10172859, Example 354 | (3,5-Dimethyl- pyrazin-2...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315930(US10172859, Example 354 | (3,5-Dimethyl- pyrazin-2...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM315930(US10172859, Example 354 | (3,5-Dimethyl- pyrazin-2...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent