BDBM316036 US10172859, Example 458::US10172859, Example 459::US10172859, Example 460::US11065253, Example 460::US9732094, Example 460::[2-Chloro-5-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]-(6-methoxy- pyridazin-3-yl)- methanol (Ena 1)1H NMR (400 MHz, DMSO-d6) ppm = 9.08 (s,1H), 8.07 (d, J = 2.2, 1H), 7.89 (d, J = 9.5, 1H), 7.73-7.67 (m, 2H), 7.63 (d, J = 8.2, 1H), 7.54 (dd,J = 9.5, 2.6, 1H), 7.24-7.19 (m, 2H), 6.59 (d,J = 4.8, 1H), 6.28 (d, J = 4.8, 1H), 4.00 (s, 3H), 3.82-3.75 (m, 4H), 3.48-3.41 (m, 4H).

SMILES COc1ccc(nn1)C(O)c1cc(ccc1Cl)-c1ncnc2cc(ccc12)N1CCOCC1

InChI Key InChIKey=QSHKWVVOMGJBJQ-UHFFFAOYSA-N

Data  6 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 316036   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataIC50: 5nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataKi:  1.25E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataKi:  1.25E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316036(US10172859, Example 459 | [2-Chloro-5-(7- morpholi...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent