BDBM316039 US10172859, Example 461::US11065253, Example 461::US9732094, Example 461::[4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- phenyl]-(3-methyl- 3H-imidazo[4,5-c]- pyridin-4-yl)methanol1H NMR (500 MHz, DMSO-d6) ppm = 9.08 (s,1H), 8.33 (s, 1H), 8.25 (d, J = 5.5, 1H), 7.62 (d,J = 5.5, 1H), 7.61-7.50 (m, 4H), 7.42-7.37 (m,1H), 7.19 (d, J = 2.3, 1H), 6.61 (d, J = 5.5, 1H), 6.43(d, J = 5.4, 1H), 4.01 (s, 3H), 3.80-3.74 (m, 4H),3.46-3.41 (m, 4H).

SMILES Cn1cnc2ccnc(C(O)c3ccc(F)c(c3)-c3ncnc4cc(ccc34)N3CCOCC3)c12

InChI Key InChIKey=NSLYODQLWMOYDK-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 316039   

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316039([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2021
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316039([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 μg of DNA-PK/protein complex and 100 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Merck Patent

US Patent
LigandPNGBDBM316039([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataIC50: 3nMAssay Description:The kinase assay was carried out in streptavidin-coated 348-well microtitre flashplates. To this end, 1.5 ug of DNA-PK/protein complex and 100 ng of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316039([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi: >2.50E+4nMAssay Description:Method for the detection and characterisation of test substances which interfere with the Kv11.1 (hERG) channel: Kv11.1 (hERG, human ether a-go-go re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Patent

US Patent
LigandPNGBDBM316039([4-Fluoro-3-(7- morpholin-4-yl- quinazolin-4-yl)- ...)
Affinity DataKi: >2.50E+4nMAssay Description:The patch-clamp measurement was carried out at room temperature in whole-cell configuration on human embryonic kidney cells (HEK293) which have been ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent