BDBM316471 US9617246, 3::US9617246, 48::methyl 2-{[(3R,6R)-6-methyl-1- {[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3- yl]sulfanyl}pyridine-3-carboxylate

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Sc1ncccc1C(O)=O

InChI Key InChIKey=WMPFJHITNNDYDR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 316471   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316471(US9617246, 48 | methyl 2-{[(3R,6R)-6-methyl-1- {[2...)
Affinity DataIC50: 23.9nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316471(US9617246, 48 | methyl 2-{[(3R,6R)-6-methyl-1- {[2...)
Affinity DataIC50: 48.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316471(US9617246, 48 | methyl 2-{[(3R,6R)-6-methyl-1- {[2...)
Affinity DataIC50: 626nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316471(US9617246, 48 | methyl 2-{[(3R,6R)-6-methyl-1- {[2...)
Affinity DataIC50: 6.54E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent