BDBM316489 2-{[(3R,6R)-1-{[4-methoxy-2-(2H-1,2,3- triazol-2-yl)phenyl]carbonyl}-6- methylpiperidin-3-yl]sulfanyl}pyridine-4- carbonitrile::US9617246, 23

SMILES COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Sc2cc(ccn2)C#N)c(c1)-n1nccn1

InChI Key InChIKey=WKSRHPMFGLRUIP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 316489   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316489(2-{[(3R,6R)-1-{[4-methoxy-2-(2H-1,2,3- triazol-2-y...)
Affinity DataIC50: 224nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316489(2-{[(3R,6R)-1-{[4-methoxy-2-(2H-1,2,3- triazol-2-y...)
Affinity DataIC50: 7.82E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent