BDBM316494 2-{[(3R,6R)-1-(biphenyl-2-ylcarbonyl)-6- methylpiperidin-3-yl]sulfanyl}pyridine-4- carbonitrile::US9617246, 28

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1ccccc1)Sc1cc(ccn1)C#N

InChI Key InChIKey=MVLJMQQXIGILAK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 316494   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316494(2-{[(3R,6R)-1-(biphenyl-2-ylcarbonyl)-6- methylpip...)
Affinity DataIC50: 16.7nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316494(2-{[(3R,6R)-1-(biphenyl-2-ylcarbonyl)-6- methylpip...)
Affinity DataIC50: 279nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent