BDBM316497 2-{[(3R,6R)-6-methyl-1-{[2-(1-methyl- 1H-pyrazol-4- yl)phenyl]carbonyl}piperidin-3- yl]sulfanyl}pyridine-4-carbonitrile::US9617246, 31

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-c1cnn(C)c1)Sc1cc(ccn1)C#N

InChI Key InChIKey=SZNZDCDBKMQXOI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 316497   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316497(2-{[(3R,6R)-6-methyl-1-{[2-(1-methyl- 1H-pyrazol-4...)
Affinity DataIC50: 30.3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316497(2-{[(3R,6R)-6-methyl-1-{[2-(1-methyl- 1H-pyrazol-4...)
Affinity DataIC50: 3.19E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent