BDBM316508 2-({(3R,6R)-6-methyl-1-[(3- pyrimidin-2-ylthiophen-2- yl)carbonyl]piperidin-3- yl}sulfanyl)pyridine-4-carbonitrile::US9617246, 42

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1sccc1-c1ncccn1)Sc1cc(ccn1)C#N

InChI Key InChIKey=LKZDFIMZVKYMKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 316508   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316508(2-({(3R,6R)-6-methyl-1-[(3- pyrimidin-2-ylthiophen...)
Affinity DataIC50: 5.30nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM316508(2-({(3R,6R)-6-methyl-1-[(3- pyrimidin-2-ylthiophen...)
Affinity DataIC50: 3.56E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2019
Entry Details
US Patent