BDBM317195 2,3-dimethyl-5-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethyl)pyrazolo[1,5-a]pyrimidine::Roche-Dataset for PDE10A, Compound 590::US9617271, 53

SMILES Cc1nn2ccc(CCc3nc(nn3C)N3CCCC3)nc2c1C

InChI Key InChIKey=IOZGPRSENVZZQC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317195   

LigandPNGBDBM317195(US9617271, 53 | 2,3-dimethyl-5-(2-(1-methyl-3-(pyr...)
Affinity DataIC50: 2.10nMAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

LigandPNGBDBM317195(US9617271, 53 | 2,3-dimethyl-5-(2-(1-methyl-3-(pyr...)
Affinity DataIC50: 17nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed