BDBM317561 3-methoxy-2-{[(3R,6R)-6- methyl-1-{[2-(2H-1,2,3- triazol-2- yl)phenyl]carbonyl}piperidin- 3-yl]amino}pyridine-4- carbonitrile::US9624197, 2

SMILES COc1c(N[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)nccc1C#N

InChI Key InChIKey=PNXOSCPXTLITPN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317561   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317561(3-methoxy-2-{[(3R,6R)-6- methyl-1-{[2-(2H-1,2,3- t...)
Affinity DataIC50: 11nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317561(3-methoxy-2-{[(3R,6R)-6- methyl-1-{[2-(2H-1,2,3- t...)
Affinity DataIC50: 267nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent