BDBM317562 2-(((3R,6R)-1-(2-(2H-Tetrazol-2-yl)benzoyl)-6-methylpiperidin-3-yl)amino)isonicotinonitrile ::US9624197, 3

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1ncnn1)Nc1cc(ccn1)C#N

InChI Key InChIKey=KDFLXCUYOVVNCG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317562   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317562(2-(((3R,6R)-1-(2-(2H-Tetrazol-2-yl)benzoyl)-6-meth...)
Affinity DataIC50: 9nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317562(2-(((3R,6R)-1-(2-(2H-Tetrazol-2-yl)benzoyl)-6-meth...)
Affinity DataIC50: 1.92E+3nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent