BDBM317566 2-((3R,6R)-1-(2-(2H-1,2,3-Triazol-2-yl)thiophene-3-carbonyl)-6-methylpiperidin-3-ylamino)-3-methoxyisonicotinonitrile::US9624197, 6

SMILES COc1c(N[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccsc2-n2nccn2)nccc1C#N

InChI Key InChIKey=IAPRICIRZAVFNL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317566   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317566(2-((3R,6R)-1-(2-(2H-1,2,3-Triazol-2-yl)thiophene-3...)
Affinity DataIC50: 11nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317566(2-((3R,6R)-1-(2-(2H-1,2,3-Triazol-2-yl)thiophene-3...)
Affinity DataIC50: 827nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent