BDBM317567 3-methoxy-2-((3R,6R)-6- methyl-1-(2-(pyrimidin-2- yl)thiophene-3- carbonyl)piperidin-3- ylamino)isonicotinonitrile::US9624197, 7

SMILES COc1c(N[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccsc2-c2ncccn2)nccc1C#N

InChI Key InChIKey=NCPASCJQPRTNKQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317567   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317567(3-methoxy-2-((3R,6R)-6- methyl-1-(2-(pyrimidin-2- ...)
Affinity DataIC50: 47nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317567(3-methoxy-2-((3R,6R)-6- methyl-1-(2-(pyrimidin-2- ...)
Affinity DataIC50: 384nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent