BDBM317569 2-{methyl[(3R,6R)-6- methyl-1-{[2-(2H- tetrazol-2-yl)phenyl]- carbonyl}piperidin-3- yl]amino}pyridine-4- carbonitrile::US9624197, 9

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)N(C)c1cc(ccn1)C#N

InChI Key InChIKey=AKVUXFVUFCVHPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317569   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317569(2-{methyl[(3R,6R)-6- methyl-1-{[2-(2H- tetrazol-2-...)
Affinity DataIC50: 32nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317569(2-{methyl[(3R,6R)-6- methyl-1-{[2-(2H- tetrazol-2-...)
Affinity DataIC50: 2.24E+3nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent