BDBM317571 3-methoxy-2- (methyl{(3R,6R)-6- methyl-1-[(2-pyrimidin- 2-ylthiophen-3- yl)carbonyl]piperidin-3- yl}amino)pyridine-4- carbonitrile::US9624197, 11

SMILES COc1c(ccnc1N(C)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccsc1-c1ncccn1)C#N

InChI Key InChIKey=NYLYNDNAWJSEIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317571   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317571(3-methoxy-2- (methyl{(3R,6R)-6- methyl-1-[(2-pyrim...)
Affinity DataIC50: 34nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317571(3-methoxy-2- (methyl{(3R,6R)-6- methyl-1-[(2-pyrim...)
Affinity DataIC50: 1.00E+4nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent