BDBM317572 2-{ethyl[(3R,6R)-6- methyl-1-{[2-(2H-1,2,3- triazol-2- yl)phenyl]carbonyl} piperidin-3-yl]amino}- pyridine-4-carbonitrile::US9624197, 12

SMILES CCN([C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1)c1cc(ccn1)C#N

InChI Key InChIKey=MFUIOLOCEHOOMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317572   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317572(2-{ethyl[(3R,6R)-6- methyl-1-{[2-(2H-1,2,3- triazo...)
Affinity DataIC50: 23nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317572(2-{ethyl[(3R,6R)-6- methyl-1-{[2-(2H-1,2,3- triazo...)
Affinity DataIC50: 1.99E+3nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent