BDBM317573 2-{[(3R,6R)-6-methyl-1- {[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin- 3-yl](prop-2-en-1- yl)amino}pyridine-4- carbonitrile::US9624197, 13

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)N(CC=C)c1cc(ccn1)C#N

InChI Key InChIKey=RCMAIVUXPZBMPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 317573   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317573(2-{[(3R,6R)-6-methyl-1- {[2-(2H-1,2,3-triazol-2- y...)
Affinity DataIC50: 23nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM317573(2-{[(3R,6R)-6-methyl-1- {[2-(2H-1,2,3-triazol-2- y...)
Affinity DataIC50: 2.55E+3nMAssay Description:FLIPR Ca2+ Flux Assay- (Okumura et al., Biochem. Biophys. Res. Comm. 280:976-981, 2001). In a typical experiment the OX1 and OX2 receptor antagonisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent