BDBM318022 8-Methyl-2-[4-[[4-trifluoromethyl)pyrimidin-2- yl]methyl]piperazin-1-yl]- 3,5,6,7-tetrahydropyrido[2,3- d]pyrimidin-4-one::US9624218, Example 16

SMILES CN1CCCc2c1nc(N1CCN(Cc3nccc(C(F)(F)F)n3)CC1)[nH]c2=O

InChI Key InChIKey=FDWCAGLPVGJZGX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318022   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Eli Lilly

US Patent
LigandChemical structure of BindingDB Monomer ID 318022BDBM318022(8-Methyl-2-[4-[[4-trifluoromethyl)pyrimidin-2- yl]...)
Affinity DataIC50: 43.4nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Eli Lilly

US Patent
LigandChemical structure of BindingDB Monomer ID 318022BDBM318022(8-Methyl-2-[4-[[4-trifluoromethyl)pyrimidin-2- yl]...)
Affinity DataIC50: 55.1nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Eli Lilly

US Patent
LigandChemical structure of BindingDB Monomer ID 318022BDBM318022(8-Methyl-2-[4-[[4-trifluoromethyl)pyrimidin-2- yl]...)
Affinity DataIC50: 187nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent