BDBM318822 US10370388, Compound Losartin::US9624243, Losartin

SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1

InChI Key InChIKey=PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 8 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318822   

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318822(US10370388, Compound Losartin | US9624243, Losarti...)
Affinity DataKi:  5.5nMAssay Description: 120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318822(US10370388, Compound Losartin | US9624243, Losarti...)
Affinity DataKi:  5.5nMAssay Description: 120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318822(US10370388, Compound Losartin | US9624243, Losarti...)
Affinity DataIC50:  11nMAssay Description: 120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. ...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetType-2 angiotensin II receptor(Human)
Novartis

US Patent
LigandPNGBDBM318822(US10370388, Compound Losartin | US9624243, Losarti...)
Affinity DataIC50:  11nMAssay Description: 120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. ...More data for this Ligand-Target Pair
In DepthDetails US Patent