BDBM318846 6-(4-chlorophenyl)-3-cyclopropyl-5-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-4(1H)-one::US9624247, Example 8

SMILES Cc1cc(cc2n(C)nnc12)N1C(c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1

InChI Key InChIKey=XMRBIQDRTZCVGG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318846   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM318846(US9624247, Example 8 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 18nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM318846(US9624247, Example 8 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 20nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM318846(US9624247, Example 8 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 28nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM318846(US9624247, Example 8 | 6-(4-chlorophenyl)-3-cyclop...)
Affinity DataIC50: 4.80E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent